Description
PROPERTIES
| Quality Level | 200 |
| sterility | 0.1 μm filtered |
| product line | BioReagentc |
| form | suspensiond |
| technique(s) | cell culture | mammalian: suitable |
| impurities | endotoxin, tested |
| color | yellow |
| antibiotic activity spectrum | Gram-negative bacteria Gram-positive bacteria fungi yeast |
| application(s) | agriculture |
| Mode of action | cell wall synthesis | interferes |
| shipped in | shipped in |
| storage temp. | −20°C |
DESCRIPTION
Application
This solution is formulated to contain 10,000 units penicillin, 10 mg streptomycin and 25μg Amphotericin B per mL, and is solubilized in a proprietary citrate buffer. It is recommended for use in cell culture applications at 10mL/L.
Antibiotic antimycotic solution has been used as a supplement in different types of cell culture media.
Biochem/physiol Actions
Mode of Action: Penicillin acts by inhibiting bacterial cell-wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome and causes miscoding. Amphotericin B interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out.
Antimicrobial spectrum: Includes Gram-negative bacteria, Gram-positive bacteria, fungi and yeasts.
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