Description
PROPERTIES
| Quality Level | 200 |
| form | powder |
| Mode of action | ≥DNA synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria Gram-positive bacteria mycobacteria |
| storage temp. | −20°C |
| SMILES string | OS(O)(=O)=O.NCCC[C@H](N)C(=O)NC[C@H]1NC(=O)[C@H](CO)NC(=O)[C@H](N)CNC(=O)[C@@H](NC(=O)C(NC1=O)=CNC(N)=O)[C@H]2CCNC(=N)N2 |
| InChI | 1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11+,12?,13+,15-,16-;/m0./s1 |
| InChI key | LFFNIXQXRKNZCE-UBBQZPMLSA-N |
DESCRIPTION
Application
Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.
Packaging
1, 5 g in glass bottle
Biochem/physiol Actions
Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44).
Preparation Note
Sparingly soluble in water.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
SAFETY INFORMATION
Pictograms : 
GHS07,GHS08
Signal Word : Danger
Hazard Statements : H302 + H312 + H332 – H360
Precautionary Statements : P201 – P280 – P301 + P312 + P330 – P302 + P352 + P312 – P304 + P340 + P312 – P308 + P313
Hazard Classifications : Acute Tox. 4 Dermal – Acute Tox. 4 Inhalation – Acute Tox. 4 Oral – Repr. 1B
Storage Class Code : 6.1D – Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK : WGK 3
Flash Point(F) : Not applicable
Flash Point(C) : Not applicable
Personal Protective Equipment : dust mask type N95 (US), Eyeshields, Gloves
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