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Clofazimine C8895-1G

6,200.00
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Tritonâ„¢ X-100 – X100-5ML

2,497.50

Clofazimine C8895-5G

22,093.83

C8895 Sigma-Aldrich

Clofazimine

Synonym(s) : N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
Empirical Formula (Hill Notation) : C27H22Cl2N4
CAS Number : 2030-63-9
Molecular Weight : 473.40
EC Number : 217-980-2
MDL number : MFCD00056793
PubChem Substance ID : 24893114
NACRES : NA.77
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SKU: C8895-5G Category:

Description

PROPERTIES

Quality Level 200
Mode of action protein synthesis | interferes
antibiotic activity spectrum mycobacteria
originator Novartis
SMILES string CC(C)N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
InChI 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key WDQPAMHFFCXSNU-BGABXYSRSA-N

DESCRIPTION

General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:

  • for antimicrobial preparation
  • to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
  • to model drug-induced hepatic granulomatous inflammation
  • to study the in vivo cargo storage capacity of macrophages

Packaging

1, 5 g in glass bottle

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

SAFETY INFORMATION

Storage Class Code : 13 – Non Combustible Solids

WGK : WGK 3

Personal Protective Equipment : dust mask type N95 (US), Eyeshields, Gloves

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