Description
PROPERTIES
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| manufacturer/tradename | Pfizer® |
| color | white to off-white |
| solubility | DMSO: >20 mg/mL |
| originator | Pfizer |
| storage temp. | room temp |
| SMILES string | CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCOCC3)c(F)c2 |
| InChI | 1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1 |
| InChI key | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
DESCRIPTION
General description
Linezolid is the first member of the oxazolidinones antibiotic class which shows wide activity against Gram-positive bacteria, including drug resistant strains.
Application
Linezolid has been used in checkerboard-type drug combination MIC (minimum inhibitory concentrations) assay to determine whether ivacaftor shows positive interaction with linezolid. It has been used for the determination of minimum biofilm inhibitory concentration and for the treatment of Mycobacterium abscessus-infected Drosophila melanogaster w1118 flies.
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
Linezolid is an oxazolidinone antimicrobial. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
SAFETY INFORMATION
Pictograms : 
GHS08
Signal Word : Danger
Hazard Statements : H372
Precautionary Statements : P314
Hazard Classifications : STOT RE 1 Oral
Target Organs : Bone
Storage Class Code : 6.1D – Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK : WGK 3
Flash Point(F) : Not applicable
Flash Point(C) : Not applicable
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