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Trizma® base T6066-5KG

24,172.23
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Linezolid PZ0014-25MG

54,709.55

Linezolid PZ0014-5MG

13,704.45

T6066 Sigma-Aldrich

Trizma® base

BioPerformance Certified, meets EP, USP testing specifications, suitable for cell culture, ≥99.9% (titration)

Synonym(s) : Tris base, Trometamol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris(hydroxymethyl)aminomethane
Linear Formula : NH2C(CH2OH)3
CAS Number : 77-86-1
Molecular Weight : 121.14
Beilstein : 741883
EC Number : 201-064-4
MDL number : MFCD00004679
PubChem Substance ID : 24900345
NACRES : NA.25
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SKU: PZ0014-5MG Category:

Description

PROPERTIES

Quality Level 100
assay ≥98% (HPLC)
form powder
manufacturer/tradename Pfizer®
color white to off-white
solubility DMSO: >20 mg/mL
originator Pfizer
storage temp. room temp
SMILES string CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCOCC3)c(F)c2
InChI 1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChI key TYZROVQLWOKYKF-ZDUSSCGKSA-N

DESCRIPTION

General description

Linezolid is the first member of the oxazolidinones antibiotic class which shows wide activity against Gram-positive bacteria, including drug resistant strains.

Application

Linezolid has been used in checkerboard-type drug combination MIC (minimum inhibitory concentrations) assay to determine whether ivacaftor shows positive interaction with linezolid. It has been used for the determination of minimum biofilm inhibitory concentration and for the treatment of Mycobacterium abscessus-infected Drosophila melanogaster w1118 flies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Linezolid is an oxazolidinone antimicrobial. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

SAFETY INFORMATION

Pictograms :  Health hazardGHS08

Signal Word : Danger

Hazard Statements : H372

Precautionary Statements : P314

Hazard Classifications : STOT RE 1 Oral

Target Organs : Bone

Storage Class Code : 6.1D – Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK : WGK 3

Flash Point(F) : Not applicable

Flash Point(C) : Not applicable

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