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15,473.40
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Vancomycin hydrochloride from Streptomyces orientalis V2002-100MG

5,117.10

Magnoflorine

14,807.40

SMB00377

Sigma-Aldrich

Magnoflorine

?98% (HPLC)

Synonym(s) : (6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol

Empirical Formula (Hill Notation) : C20H24NO4

CAS Number : 2141-09-5

Molecular Weight : 342.41

MDL number : MFCD09031380

PubChem Substance ID : 329824978

NACRES : NA.25

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SKU: SMB00377-10MG Category:

Description

PROPERTIES

Quality Level 200
assay ?98% (HPLC)
form powder
storage temp. 2-8?C
SMILES string OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32
InChI 1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
InChI key YLRXAIKMLINXQY-ZDUSSCGKSA-O

Description

General description

Magnoflorine is a secondary metabolite and an alkaloid with a quaternary aporphine configuration. It can be found in roots, rhizomes, stems, barks, or seeds of many herbal plants such as Caulophyllum thalictroides (blue cohosh), Arisolochai bracteate, P. amurense, S. acutum, Tinospora crispa, Coptidis rhizome, etc. Magnoflorine constitutes approximately 65 % of the total alkaloids in roots and rhizomes of blue cohosh. It is also known as thalictrine and escholine.

Application

Magnoflorin has been used to test its contractile effects on isolated mouse uterine smooth muscle tissues and on isolated strips of Mus musculus distal colon smooth muscle tissues.

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Magnoflorine possesses several biochemical and pharmacological properties such as antioxidant, anti-inflammatory, immunomodulatory, anti-diabetic, anti-fungal, cardiovascular protective, and neuropsychological. It also acts as an ?-tyrosinase inhibitor. It helps to increase pro-inflammatory responses induced by lipopolysaccharide (LPS). It exerts antitumor, anti-cancer activities by inhibiting gastric cancer progression gastric cancer cell xenograft mouse model.

SAFETY INFORMATION

Pictograms GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332
Precautionary Statements P261 – P280 – P301 + P312 + P330 – P302 + P352 + P312 – P304 + P340 + P312
Hazard Classifications Acute Tox. 4 Dermal – Acute Tox. 4 Inhalation – Acute Tox. 4 Oral
Storage Class Code 13 – Non Combustible Solids
WGK WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable

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