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Vancomycin hydrochloride from Streptomyces orientalis V2002-100G

630,147.00

V2002

Sigma-Aldrich

Vancomycin hydrochloride from Streptomyces orientalis

potency: ?900 ?g per mg (as vancomycin base)

Empirical Formula (Hill Notation) : C66H75Cl2N9O24 ? HCl

CAS Number : 1404-93-9

Molecular Weight : 1485.71

Beilstein : 3704657

PubChem Substance ID : 24900723

NACRES : NA.85

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SKU: V2002-100G Category:

Description

PROPERTIES

Quality Level 200
biological source Streptomyces orientalis
form powder
potency ?900 ?g per mg (as vancomycin base)
storage condition (Keep container tightly closed in a dry and well-ventilated place.)
color white to brown
solubility H2O: 50 mg/mL
Mode of action cell wall synthesis | interferes
antibiotic activity spectrum Gram-positive bacteria
storage temp. 2-8?C
SMILES string Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4

Description

General description

Chemical structure: glycopeptide

Application

Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (?-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients. Vancomycin?s overuse has been studied, which has resulted in recommended guidelines.

Packaging

1, 5 g in glass bottle

100, 250 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

Vancomycin is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It is effective against Gram-positive bacteria. Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis.

Glycopeptide antibiotic

Mode of action: Used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.
Antimicrobial spectrum: Gram-positive bacteria

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

SAFETY INFORMATION
Pictograms GHS08
Signal Word Danger
Hazard Statements H317 – H334
Precautionary Statements P261 – P272 – P280 – P284 – P302 + P352 – P304 + P340 + P312
Hazard Classifications Resp. Sens. 1 – Skin Sens. 1
Storage Class Code 11 – Combustible Solids
WGK WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

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