Description
PROPERTIES
| Quality Level | 200 |
| biological source | Streptomyces orientalis |
| form | powder |
| potency | ?900 ?g per mg (as vancomycin base) |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place.) |
| color | white to brown |
| solubility | H2O: 50 mg/mL |
| Mode of action | cell wall synthesis | interferes |
| antibiotic activity spectrum | Gram-positive bacteria |
| storage temp. | 2-8?C |
| SMILES string | Cl[H].CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]2C[C@](C)(N)[C@@H](O)[C@@H](C)O2.CN[C@H](CC(C)C)C(=O)NC3[C@H](O)c4ccc(Oc5cc6Oc7ccc(cc7Cl)[C@@H](O)[C@H]8NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC3=O)c(c5)c6)c9ccc(O)c(c9)-c%10c(O)cc(O)cc%10[C@@H](NC8=O)C(O)=O)c(Cl)c4 |
Description
General description
Chemical structure: glycopeptide
Application
Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (?-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients. Vancomycin?s overuse has been studied, which has resulted in recommended guidelines.
Packaging
1, 5 g in glass bottle
100, 250 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.
Biochem/physiol Actions
Vancomycin is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It is effective against Gram-positive bacteria. Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis.
Glycopeptide antibiotic
Mode of action: Used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.
Antimicrobial spectrum: Gram-positive bacteria
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
SAFETY INFORMATION
| Pictograms | GHS08 |
| Signal Word | Danger |
| Hazard Statements | H317 – H334 |
| Precautionary Statements | P261 – P272 – P280 – P284 – P302 + P352 – P304 + P340 + P312 |
| Hazard Classifications | Resp. Sens. 1 – Skin Sens. 1 |
| Storage Class Code | 11 – Combustible Solids |
| WGK | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
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